The ULT25NEU with SenseAnywhere:
A Complete Solution for Clinical ULT Applications

By Jennifer Shrider, Marketing Coordinator

The Stirling Ultracold ULT25NEU is the only portable and deployable ultra-low temperature (ULT) freezer on the market for the clinical storage of temperature-sensitive drugs and treatments. Now it’s simpler than ever to ensure the viability of therapies collected at remote clinical sites with the new ULT25NEU and the SenseAnywhere wireless temperature monitoring system. This system makes it easy and affordable to monitor the temperatures of samples from any location and on any device with a browser through a secure Cloud.

The ULT25 equipped with SenseAnywhere provides a reliable cold storage solution close to the patient, while also allowing treatment providers and clinical trial managers to monitor and audit the safe storage of valuable medications and therapies from afar. This is ideal for providers of regenerative, cellular, genetic and immuno therapies who need to validate the viability of temperature-sensitive treatments at multiple remote clinical locations. With the addition of the SenseAnywhere system, you can establish and centrally maintain an audit trail of sample temperature data for a remote fleet of ULT25 freezers at hospitals, surgery centers and clinical trial sites. SenseAnywhere is FDA compliant to 21 CFR Part 11 for data integrity as well as meeting the EN 12830:2018 standard for temperature recorders for transport, storage and distribution of temperature-sensitive goods.

The key features of the SenseAnywhere system include:

• Accurate freezer temperature monitoring with a multi-point calibrated RTD probe, including ambient temperature conditions around the freezer

• Customizable instant alarms will notify you via email and/or text when limits are surpassed

• Historical and real-time 24/7 data available to track for compliance

• Secure data storage with access anytime and anywhere via a secure Cloud

SenseAnywhere’s AiroSensor model

There are many additional benefits of the SenseAnywhere system such as having no software to install (connect via an AccessPoint and site Ethernet, or cellular data), no backups required and no maintenance. It’s waterproof and the battery life is guaranteed for 10 years. Once you register online at the SenseAnywhere client portal you can manage the settings of your connected device, view graphs, set alarm profiles and schedule/download reports.

The ULT25, equipped with the SenseAnywhere system, is the complete ULT solution for clinical point-of-use storage, patient drug delivery and the remote collection of samples, all while having secure temperature monitoring throughout the process. Exceptional sample safety and data tracking have never been so effortless to maintain until now.

To learn more about the portable ULT25NEU freezer, download the brochure »

Shuttle Freezer Delivers Unique Cancer Treatment Solution

By Jennifer Shrider, Marketing Coordinator

Stirling Ultracold’s ULT-25NE Shuttle™ freezer is the only portable, deployable solution available today that can bring your ultra-low temperature (ULT) storage directly to the patient. The Shuttle freezer is ideal for clinical trials, biologic drug and immunotherapy delivery because it is small, energy-efficient and plugs into any outlet or DC power from an automobile adapter. This ULT freezer will keep injectable biologic drugs safe due to the reliability of the free-piston Stirling engine. 

Biotechnology company, Amgen Inc., has developed the first and only FDA-approved oncolytic viral therapy called IMLYGIC®, which treats melanoma skin cancer lesions that have returned after surgery. Frozen IMLYGIC® vials require a transport and storage temperature range of -90°C to -70°C. IMLYGIC® must be stored in the carton and protected from light until ready to use.

Amgen is utilizing the Shuttle freezer to store IMLYGIC® in a clinical environment. The Shuttle freezer is an ideal storage solution for clinicians, hospitals and treatment centers because it is lightweight and easily maneuverable. To view a video that explains the storage and handling of IMLYGIC®, and features the Shuttle freezer starting about 5 minutes into the program, check out the webpage link here.

Shuttle freezer in the IMLYGIC® video at 6:52

It’s inspiring to see our ultra-low freezer being used on the front lines of fighting disease and improving the lives of cancer patients every day. 

IMLYGIC® is a trademark of Biovex, Inc., a subsidiary of Amgen, Inc.

 

New “High-Density” Rack: Even More ULT Storage Capacity in the Same Space

By Jim Miller, Stirling Ultracold Chief Revenue Officer

Our 600-box SU780XLE ultra-low freezer already stores the most samples per floor space area of any comparable model. With the new “High-Density” Storage Rack solution, it can now store 100* more boxes in the same footprint! Storing up to 700* two-inch sample boxes, this optional rack solution further increases the freezer’s storage density to 81.6 boxes per sq. ft/m of floor space, which is 35-70% more ULT storage per floor space area than similarly-sized freezer models.

The High-Density Storage Rack is a perfect solution for laboratories and biorepositories with limited space who want to expand biological sample inventories without new construction. The ability to store more samples in a smaller freezer footprint not only reduces your cost per sq. ft/m, but offers the potential of replacing older ULT models with fewer freezers to reduce capital costs.

Considering that the SU780XLE is the most energy-efficient ENERGY STAR®-certified ULT freezer, this new 700-box rack furthers its efficiency per sample. In fact, the XLE uses 20-60% less energy per sample than other ENERGY STAR-certified ULT freezers (energy consumption data source: energystar.gov) in the high-density configuration. This not only enhances energy savings for all users, and potentially reduces the number of units required, but particularly benefits commercial biorepositories by improving profitability with the lowest operating cost per sample stored.

To learn more, download our new High-Density Storage Rack brochure

* To keep the vacuum release port unobstructed on the SU780XLE, it is recommended that one box be removed from the High-Density Storage Rack. This will reduce storage capacity to 699 2-inch boxes in the high-density configuration.

Stirling Ultracold Helps Australia’s Telethon Kids Institute Improve the Lives of Children

By Nicholas A. Pezzuolo, VP of Channel Development

As we expand our global market presence, it’s great when we can share how Stirling Ultracold products are making an impact in regions all over the world. One example from earlier this year is the Telethon Kids Institute in Nedlands, Western Australia which purchased and installed 23 of our SU780XLE ultra-low temperature freezers (see photo to the right) through our distributor partner Bioline Global Pty Ltd. The Institute is located within the Perth Children’s Hospital and is one of the largest research facilities in Australia. Telethon is committed to improving the lives of children through extensive research in childhood diseases, conditions, and issues. Their four main areas of focus are Aboriginal Health, Brain and Behavior, Chronic and Severe Diseases, and Early Environment.

Telethon has also pledged to reduce their carbon footprint by embracing sustainable practices for the well-being of all children in the present and future. We are proud that Telethon chose our reliable, energy-efficient freezers to help them meet their environmental goals.

Ottawa Hospital Reduces HVAC Load & Cost by Replacing ULT Freezer with SU780XLE

by Tim Root, Director of Marketing

At Stirling Ultracold, we’re always delighted to hear stories about our products helping customers save money and achieve their sustainability goals. That’s why we were pleased to see Ottawa Hospital sharing good news about how they saved energy by replacing old ULT freezers with energy-efficient models, including our SU780XLE. As recently reported in their newsletter article, Research deep freezers reduce energy consumption by 85%, Ottawa Hospital Research Institute (OHRI) has already saved about $20,000 in utility costs per year.

Hospital researchers have not only reduced energy consumption and carbon footprint, but were surprised by how quiet the energy-efficient models operate; in addition to how much less heat they generate.

As noted in the article by Brian Cayen, Research Information Services and Operations Manager, replacing just one of OHRI’s old ULT freezers with our SU780XLE model made an immediate impact on HVAC load and comfort in the lab . . .

“The first freezer that was replaced in one of the labs reduced heat generation and allowed us to turn off one of the two air conditioning units, and the temperature in the room still dropped by 2°C.”

With benefits for laboratory, operations and sustainability teams at OHRI, this article cites another real-world example of how Stirling ULT freezers deliver tangible advantages across the entire research organization.

 

How to Get 15-50% More ULT Sample Storage from Your Limited Floor Space

At Stirling Ultracold, we recognize that laboratories and biorepositories have a limited amount of floor space. That’s why our unique ULT freezer design delivers more storage capacity per square foot than other comparable models, giving you the most use of your floor space. With our compact Stirling engine cooling technology, less than 11% of our SU780XLE’s outer cabinet volume is needed to house its mechanical cooling system. That’s remarkably smaller than compressor deck space required in other ULT freezers, which is why you get so much more storage capacity in a smaller footprint with a Stirling freezer.

How Much More Sample Storage Do You Get Per Square Foot?
Our unique freezer design allows you to store 15-50% more 2ml vials per square foot of floor space (per freezer) when compared to other upright models of similar size.

Here’s another way to look at this . . . With the smaller footprint of our 600-box-capacity SU780XLE, you can place two additional ULT freezer units in a 50-foot row (side-by-side arrangement with recommended clearance), versus competitive models. This equates to a difference in storage capacity of 1,200-2,200 additional 2” sample boxes, or 120,000-220,000 additional sample vials within the same floor space!

Also, the Stirling Ultracold SU780XLE can be placed directly against the walls in your space, whereas competitive models require an additional 6-8 inches behind the freezer for ventilation clearance. This increases our footprint advantage even further. 

Our Stirling engine cooling technology is located at the top of our freezers, inside the green top. This places more racks within easier reach, while significantly improving system access and serviceability. In other ULT freezers, compressor-based cooling systems are located at the bottom of the freezer where service access is more limited.

With our innovative cooling system and unique design, we provide the most ULT storage capacity for your limited floor space, in addition to keeping your samples safer than they’ve ever been.

Congratulations to the 2017 Freezer Challenge Winners

Last December, we told you about the North American Laboratory Freezer Challenge, a collaboration of the I2SL and My Green Lab that promotes sample integrity, accessibility, reduced costs, and energy efficiency. As one of the Presenting Sponsors of the Freezer Challenge, we would like to congratulate the winners of this friendly competition that were recently announced.

The Freezer Challenge organizational winners were:

The individual laboratory winners were:

  • The Hoekstra Lab from Harvard University
  • The Baker Lab from Lilly
  • The Jones Lab from the CDC

Even more significant than the winners named above, Freezer Challenge participants collectively saved approximately 2.7-million kWh/year (equivalent to ≈1,900 metric tons of carbon emissions) and discarded over 200,000 samples.

We’re thrilled to have been a part of the Freezer Challenge program because it shares our core values, as exemplified by our 100% sustainable product line and Zero Waste facility. We’re also looking forward to presenting the awards to these winners at the 2017 I2SL Annual Conference on October 16 in Boston, MA.

For more information on the winners, please read the announcement from the Freezer Challenge website and the recent article on Nature.com.”

 

 

 

Our Undercounter ULT Freezer: Convenient, Compliant Personal Storage

When you don’t have enough room for a full-size ULT freezer in your lab or clinical space, Stirling Ultracold offers a smaller version of our upright freezer with the same award-winning Stirling engine technology: our SU105UE (105) undercounter ULT freezer. The 105 is a personal and lockable ULT freezer that is ideal for placing under or near your bench in the lab. This stackable model uses the revolutionary free-piston Stirling engine technology found in our SU780XLE Upright Freezer, offering a highly reliable ULT storage solution with only two moving parts, no oil and no compressors. We’ve packed convenience and reliability into one ULT freezer.

Undercounter Convenience and Space Savings- The light-weight (220 lbs./99 kg) SU105UE model is the right size for positioning under your workbench or nearby, with a surprising amount of storage space. It holds 72 two-inch boxes, making the most of its compact footprint. The quiet Stirling engine puts out much less heat than compressor-based models, providing a mixture of convenience and comfort to your work space. These benefits paired with quick and easy access allow you more time to focus on your research.

Stackable Flexibility- The SU105UE is stackable with full access to samples in an over / under configuration. This is particularly useful for placing ULT storage in labs with limited floor space, and for “staging” sample temperatures. With the widest temperature range in its class, the 105 can store biological materials from -86˚C up to -20˚C. This is ideal for clinical samples and biological drugs that must be warmed to a specific temperature in stages.

 

A “Temperature Stack” Case Study –

One example of the SU105UE’s stackable flexibility can be found at a research lab in Western Pennsylvania, where the team is taking advantage of the 105’s stackability, as well as its uniquely wide temperature range. This lab is working with a biologic drug that must be transitioned from  -80˚C to room temperature in two stages. With the range of -86˚C up to -20˚C, one of the freezers in the stack is used for the intermediate stage of the transition. Placing 105s in a stack offers a unique level of convenience and space-savings in this situation, with the flexibility to use the same freezer model at dissimilar temperatures ranges. This research team has seen improved efficiency and accuracy in the transition of these biologic materials to room temperature, while conserving precious floor space in their lab.

Secure Personalized Storage – The SU105UE model is the perfect size for personalized ULT storage. It gives you the freedom and control to organize your samples in a way that makes the most sense to you and your research. The 105 is also lockable to keep samples secure. Having a smaller lockable chamber is ideal for clinical use, where HIPAA patient privacy and access compliance standards are involved.

All the Advantages of Stirling Engine Technology – Like all of Stirling Ultracold freezers, the SU105UE can plug into any outlet worldwide, including 120V – 240V 50/60 hz. Consuming less than 4 kWh/day at -80°C, it saves energy and is environmentally friendly with 100% natural refrigerants. Because the 105’s advanced Stirling engine cooling system is inherently reliable, it comes with an industry-leading warranty that includes 7 years engine protection, with 2 years and labor cover parts coverage in the U.S. and Canada.

The SU105UE provides the perfect blend of safety, security and flexibility for your lab which will allow you to be more productive than ever.

ULT Technology That Advances Both Energy-Efficiency and System Reliability

Perhaps you’re aware of the free-piston Stirling engine that allows Stirling Ultracold ultra-low temperature (ULT) freezers to use less than a third the energy of legacy, compressor-based models. You may also know that this enabling technology, not only saves energy and associated operating costs, but uses 100% natural refrigerants that substantially reduce ozone-depleting and greenhouse gas emissions. However, you may not realize that the Stirling engine also advances the safety of biological samples with its inherent reliability advantages.

From the outset, Stirling Ultracold has believed that sustainable, energy-efficient ULT technology would present a very compelling choice for the research community, and we are pleased to see the recent efforts of some compressor-based ULT manufacturers to improve the efficiency of their cascade technologies.

However, it should be noted that energy efficiency was never our sole reason for bringing Stirling engine technology to laboratory cold storage. Improvements in ULT efficiency and sustainability, while important on their own merits, should always support or enhance the reliability of cooling systems that preserve valuable samples for research. The inherent reliability of the Stirling engine, while less understood, is vitally needed in our industry to further the safe preservation of biological specimens.

This innovation delivers several reliability advantages that address well-known failures associated with aging technologies used in most ULT freezers. To understand this, let’s first look at the basic differences between cascade-compressor and Stirling engine systems . . .

Unlike “cascade systems” with two compressors and cooling loops in a cascading arrangement, the Stirling engine uses a single reciprocating piston and a continuous, gravity driven thermosiphon to cool the cabinet interior. In contrast to standard cascade systems that regulate temperatures by switching compressors on and off, the Stirling engine’s linear motor system continuously modulates and adapts by controlling the motion of the free piston.

How Does the Stirling Engine Improve ULT System Reliability?
Below are several key design attributes and innovations that extend the operating life of the Stirling engine and address the common reasons why conventional ULT systems fail . . .

  • The advanced integral linear motor system has only two moving parts.
  • The moving parts never wear because gas bearings eliminate physical contact (friction) during motion
  • There is no oil to clog up the system or lubrication levels to maintain.
  • There are no valves to fail or maintain
  • 100% adaptive, continuous modulation regulates temperatures without stop-start cycles.
  • Electromechanical stress and amperage peaks from on-off surge currents have been eliminated.
  • Minimal preventive maintenance is required for reliable cooling operation.

If you would like a more in-depth understanding of how advanced ULT technology can reduce your energy consumption, while also improving reliability and sample safety, talk to your Stirling Ultracold representative or contact us at sales@stirlingultracold.com.

Stirling Ultracold Freezers Now Available on GSA Advantage

SDVOSB & GSA Advantage
Stirling Ultracold products are available on GSA Advantage through, Pulcir, Inc., a CVE VetBiz Certified Disabled Veteran Owned Small Business – Contract GS-07F-0360W

We are excited to announce that all Stirling Ultracold ultra-low temperature (ULT) freezers and accessories are now available for purchase through the U.S. General Services Administration and the GSA Advantage website. Through our distributer Pulcir, Inc., U.S. government agencies may now benefit from the ease and efficiency of the GSA preapproved procurement process when buying our ULT freezer products.

Procurement of Sustainable and Responsible, U.S. Manufactured Products

With the availability of Stirling freezers on the GSA Advantage website, it is now easier for government agencies and research laboratories to support federal sustainability initiatives with the purchase of our energy efficient ULT freezers that use 100% natural refrigerant in place of ozone-depleting HFCs. Because Stirling Ultracold products are made in in Athens, Ohio, the purchase of our ULT freezers supports U.S. manufacturing jobs in a historically underserved Appalachian business zone. In addition, our products are available on GSA Advantage exclusively through our new distributor, Pulcir, Inc., a CVE VetBiz Certified Disabled Veteran Owned Small Business (Contract GS-07F-0360W). At Stirling, our goal is to provide ultra-low temperature freezers to the research community in a way that is socially and environmentally responsible.

Easy Ordering Online

Ordering a Stirling Ultracold ULT freezer or accessory through the GSA Advantage website is quick and easy:

  1. Visit www.gsaadvantage.gov
  2. Type “Stirling Ultracold” within the product search box
  3. Browse our product line of ULT freezers and accessories
  4. Purchase with ease and confidence

For more information about U.S. government agency purchasing of Stirling Ultracold products through GSA Advantage, you can contact Pulcir at 865-272-5338 or send an email message to Nick Pezzuolo at npezzuolo@stirlingultracold.com.